Effect of Omeprazole, Amoxicillin and Metronidazole Triple Therapy on the Helicobacter Pylori (HP) Associated Digestive Ulcer

Objective To evaluate the triple therapy of Omeprazole,Amoxicillin and Metronidazole on the HP associated digestive ulcer. Methods 85 HP positive patients with duodenal and/or gastric ulcer were divided into two groups randomly. The first group (43 cases) received two-week treatment with Omeprazole (20mg), Amotronidazole (400mg) twice daily, Amoxicillin (500mg) four times daily; The second group received one-week treatment with the same methods as the first group, and continued to get one-week treatment of Omeprazole (200mg) once daily. Four weeks after completing this treatment, all patients had repeated HP and endoscopic examination. Results 5 patents in the first group were excluded because of anaphylactic dermatitis, 38 patients' results were analysed statistically. The eradication rate of the first and the second group was 89.4% and 83.3% respectively. The duodenal and/or gastric ulcer healing rate of them was 92.1% and 88.1% respectively.Conclusion The HP eradication and digestive ulcer healing rates of the first group were higher than that of the second group, but there is no significant difference between these two groups (P0.05). Our data showed that both groups have an ideal ulcer healing and HP eradication rates after the triple therapy.