The cruative effect of omeprazole triple therapy in Hp-related peptic ulcer

Objective To explore the curative effect of omeprazole triple therapy in the treatment of Helicobacter pylori(Hp)-related peptic ulcer.Methods Sixty patients with Hp-positive peptic ulcer were randomly divided into treatment group and control group,with 30 patients in each group.The treatment group was treated with capsules of omeprazole,amoxicillin and metronidazole,while the control group was treated with rabeprazole,amoxicillin and metronidazole,continuously orally taking before meals for two weeks.After four weeks of treatment,the two curative effects were observed including the relief of clinical symptoms,the situation of ulcer healing and Hp eradication according to the gastroscopy examination.Results In treatment group,the ulcer healing rate was 80%,the efficive rate was 13.3%,the total effective rate was 93.3%;In control group,the ulcer healing rate was 73.3%,the efficive rate was 16.7%,the total effective rate was 90.0%;Hp eradication rate was 90.0%in treatment group,and 93.3%in control group.There was no significant statistically difference was not significant in the curative effect between two groups(P 0.05 ).Conclusion Triple therapy with omeprazole,amoxicillin and metronidazole for Helicobacter pylori-related peptic ulcer has advantages of good efficacy,short course,good compliance and low cost,and is suitable for primary hospitals to promote the application.