Expression of mRNA of matrix metalloproteinase 11 and Moesin and its relevance to metastasis and prognosis in colorectal carcinoma

Objective To determine the expression of mRNA of matrix metalloproteinase 11(MMP-11) and Moesin in colorectal carcinoma tissue,and to investigate the correlation between its expression and tumor metastasis and prognosis.Methods The expressions of mRNA of MMP-11 and Moesin in 68 tissues from patients with colorectal carcinoma and 40 tissues with normal colorectal mucosa were detected with in situ hybridization.Results The positive expression of mRNA of MMP-11 and Moesin in colorectal carcinoma tissue was 69.1%,and 60.3% respectively,which were both significantly higher than that in normal colorectal mucosa(P 0.05).The expression of mRNA of MMP-11 and Moesin was correlated with histologic differentiation,lymph node metastasis and clinical staging in patients with colorectal carcinoma.The expression of MMP-11 mRNA was also correlated with the depth of invasion of colorectal carcinoma into tissues(P 0.05).The 5-year survival rates were 46.8% and 75% in colorectal carcinoma patients with positive and negative expression of MMP-11 mRNA,respectively.The difference was statistically significant(P 0.05).There were no significant differences on the 5-year survival rates between the colorectal carcinoma patients with positive and negative expression of Moesin mRNA.Conclusion The expressions of mRNA of MMP-11 and Moesin are correlated with the progression and metastasis of colorectal carcinoma,and MMP-11 may be used as a predictor for prognosis of colorectal carcinoma.