Protective effect of ulinastatin on the organ of patients with severe sepsis in emergency department

Objective To study the protective effect of ulinastatin (UTI) on the organ of patients with severe sepsis. Methods A total of 86 patients with severe sepsis were randomly divided into the ulinastatin treatment group (UTI group, n=45) and routine treatment group (control group, n=41). All the patients in the two groups received routine treatment, while those in UTI group were additionally treated with 200 000 U ulinastatin intravenously every 8 hours for 7 days. The C-reactive protein (CRP), white blood cells (WBC), oxygenation index (PaO2/FiO2), alanine aminotransferase (ALT), creatinine (Cr), APACHE-Ⅱ values and the incidence of multiple organ dysfunction syndrome (MODS) were detected before treatment and on the 1st, 3rd, 7th day after treatment. Results On the 1st, 3rd, 7th day after treatment, the levels of CRP, WBC, ALT, Cr in UTI group were reduced significantly than those in the control group (P0.05).No statistically significant difference was found in the above-mentioned values before treatment between the two groups. On the 1st, 3rd, 7th day after treatment, PaO2/FiO2 was significantly improved in UTI group than in the control group (P 0.05), the APACHE-Ⅱ values were significantly decreased (P0.05), and the incidence of MODS was significantly lower (P0.05). Conclusion For patients with severe sepsis at emergency, Ulinastatin can effectively alleviate the disease, improve the inflammatory reaction and oxygenation index, protect the important organs of patients, as well as prevent MODS.