Effects of ulinastatin on inflammatory response and curative effect in severe sepsis patients

Objective To study the effects of ulinastatin(UTI)on inflammatory response in the patients with severe sepsis and to evaluate the curative effect of UTI.Methods 63 patients of severe sepsis were randomly divided into three groups.Control group(groupⅠ,n=21),UTI 10 000 U·kg-1·d-1 group(groupⅡ,n=21),UTI 20 000U·kg-1·d-1 group(groupⅢ,n=21).Before treatment and on 120th hour after the treatment,blood samples were taken from peripheral veins for the determination of TNF-α,IL-1β,IL-10,MDA and SOD activities,simultaneously APACHEⅡ scores were recorded.Mortality rate was compared on 28th day.Results The indexes of three groups were similar before treatment.On 120th hour after the treatment,the venous blood levels of TNF-α,MDA and APACHEⅡ score,the 28-day mortality rate in groupⅡ and Ⅲ were significantly lower than those in groupⅠ(P〈0.05),the venous blood levels of IL-10,SOD in groupⅡ andⅢ were significantly higher than those in group I(P〈0.05),the venous blood levels of TNF-a,MDA in groupⅢ were significantly lower than those in groupⅡ(P〈0.05),the venous blood levels of IL-10 in groupⅢ were significantly higher than those in groupⅡ(P〈0.05).Conclusions UTI can inhibit inflammatory response in patients with severe sepsis and reduce 28-day mortality.UTI 20 000 U·kg-1·d-1 group is superior to UTI 10 000 U·kg-1·d-1 group in inhibiting inflammatory response.