CD146,VEGF and their correlations with angiogenesis in prostate cancer

Objective To study the expression of CD146 and VEGF in prostate cancer tissue and their relationship with tumor angiogenesis.MethodsImmunohistochemical SP method was used to detect the expression of CD146 and VEGF in 39 cases of prostate cancer tissue and 20 cases of benign prostatic hyperplasia(BPH)tissue,the microvessel density(MVD)marked by CD34 was also detected.ResultsThe positive expression rate of CD146 in prostate cancer tissue(82.05%)was remarkably higher than that BPH tissue(15.00%,P0.05).The expression of CD146 was not correlated with the pathological grade of prostate cancer(P0.05),contrasting to significant correlation to clinical stage(P0.05).The positive expression rate of VEGF in prostate cancer tissue(74.36%)was significantly higher than that in BPH tissue(10.00%,P0.05).In prostate cancer,the expression of VEGF was significantly correlated with the pathological grade and clinical stage(P0.05).The MVD of prostate cancer tissue(37.41±7.95)was significantly higher than that of BPH tissue(17.62±2.40,P0.05).The MVD of prostate cancer was significantly correlated with the pathological grade and clinical stage(P0.05).The MVD values in CD146 positive(39.73±6.68)and VEGF positive(40.79±6.03)groups was significantly higher than those in CD146 negative and VEGF negative groups(26.83±3.24、27.62±3.24,all P0.05).There was a positive correlation between expression of CD146 and VEGF in prostate cancers(r=0.643,P0.05).ConclusionsThe overexpression of CD146 and VEGF in prostate cancers have a significant relation with tumor angiogenesis.The expression of CD146,VEGF and angiogenesis closely correlate with the development,progress and metastasis of prostate cancer.