Correlation between the expression of c-met and HER-2 in breast cancer tissues and clinical pathological factors

OBJECTIVE:To detect the expression of c-met and HER-2gene in breast cancer,and analyze the correlation between c-met and HER-2expression and clinical pathology and molecular biology information.METHODS:The clinical and pathological data of 106 cases of breast cancer who were treated in Linyi People's Hospital from 2005-06-10to2012-02-20 was analysed retrospectively.The c-met gene and HER-2gene were detected by immunohistochemistry method.The correlation between c-met and HER-2expression and correlation between clinical pathological factors were analyzed.RESULTS:Positive expression rates of c-met and HER-2in 106 cases of breast cancer tissue were 64.15%(68/106)and 50.94%(54/106);Positive expression rates of ER and PR were 59.43%(63/106)and 50.00%(53/106).The expressions of HER-2gene had correlation with the axilla lymph node metastasis(P=0.001)and tumor clinical staging(P0.001).The expressions of c-met gene had correlation with the axilla lymph node metastasis(P=0.004)and tumor clinical staging(P=0.001).The expression had no correlation with the tumor diameter and the estrogen receptor and progesterone receptor expression rate.There was no correlation between the expression of HER-2gene and c-met gene(r=0.071,P=0.172).CONCLUSION:Combined detection of c-met and HER-2gene are of great importance in the predicting the lymph node metastasis,prognosis judgement and clinical comprehensive treatment performation.