Effect on proteinuria in the early diabetic nephropathy case with prostaglandin E_1 and Shenkang injection

OBJECTIVE To observe the effect on proteinuria in the early diabetic nephropathy case with prostaglandin E1 and Shenkang injection.METHODS 44 patients with early diabetic nephropathy were divided randomly into four groups.11 patients were treated with 10 g Lipo PGE1 daily for 14 days. 11 patients were treated with 100 mL Shenkang injection daily for 14 days.13 patients were treated with 10 g Lipo PGE1 and 100 mL Shenkang injection daily for 14 days.9 patients in control group.RESULTS In treating group (Lipo PGE1 group,Shenkang injection group and the combination treatment group),proteinuria and albuminuria were significantly reduced as compared with the control group (P0.05).Among them ,blood BUN,SCr in the Shenkang injection group and combination treatment group were also declined (P0.05). Compared with groups, Proteinuria, albuminuria and blood BUN SCr of the combination treatment group were decreased more than the Lipo PGE1 and Shenkang injection group (P0.01).CONCLUSION Both prostaglandin E1 and Shenkang injection may decrease proteinuria for early diabetic nephropathy,but combination treatment may be better.