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2008•China Medical HeraldRequires access

The expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia

Yuemei Wu

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Abstract

Objective:To investigate the expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia, as well as the effects on the angiogenesis of BPH.Metheds:Immunohistochemical S-P assay was used to investigate the expressions of vascular endothelial growth factor and microvascular density in twenty-three cases of BPH.Results:The positive rates of VEGF in the center part and circumjacent part of BPH were 54.35% and 13.48% respectively, and it showed a significant difference(P0.01).The average MVD values in the center part and circumjacent part of BPH were(20.39±6.45)and(7.45±4.34)respectively, and it also showed a significant difference(P0.01).There was a correlation between VEGF expression and MVD value(r=0.863 4, P0.05)。Conclusion:VEGF is a key factor in promoting the BPH angiogenesis.

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What this paper is about

Objective:To investigate the expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia, as well as the effects on the angiogenesis of BPH.Metheds:Immunohistochemical S-P assay was used to investigate the expressions of vascular endothelial growth factor and microvascular density in twenty-three cases of BPH.Results:The positive rates of VEGF in the center part and circumjacent part of BPH were 54.35% and 13.48% respectively, and it showed a significant difference(P0.01).The average MVD values in the center part and circumjacent part of BPH were(20.39±6.45)and(7.45±4.34)respectively, and it also showed a significant difference(P0.01).There was a correlation between VEGF expression and MVD value(r=0.863 4, P0.05)。Conclusion:VEGF is a key factor in promoting the BPH angiogenesis.

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Available abstract

Objective:To investigate the expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia, as well as the effects on the angiogenesis of BPH.Metheds:Immunohistochemical S-P assay was used to investigate the expressions of vascular endothelial growth factor and microvascular density in twenty-three cases of BPH.Results:The positive rates of VEGF in the center part and circumjacent part of BPH were 54.35% and 13.48% respectively, and it showed a significant difference(P0.01).The average MVD values in the center part and circumjacent part of BPH were(20.39±6.45)and(7.45±4.34)respectively, and it also showed a significant difference(P0.01).There was a correlation between VEGF expression and MVD value(r=0.863 4, P0.05)。Conclusion:VEGF is a key factor in promoting the BPH angiogenesis.

Key concepts: Medicine, Vascular endothelial growth factor, Angiogenesis, Hyperplasia, Significant difference, VEGF receptors, Immunohistochemistry, Pathology

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