A control study of ziprasidone vs.Lithium carbonate in the treatment of the therapy of bipolar disorder manic episode

Objective To explore the efficacy and safety of quetiapine vs.Lithium carbonate in the treatment of bipolar disorder manic episode(BDME).Methods Sixty-eight BDME patients were randomly assigned to two groups of 34 ones each,research group took orally quetiapine and control group did lithium carbonate for 6 weeks.Clinical efficacies were assessed with the Beck-Rafaelsen Mania Scale(BRMS) and Treatment Emergent Symptom Scale(TESS) before treatment and at the end of the 2nd,4th and 6nd week.Results Score of study group decreased significantly than the control group in the second week,the difference between groups was significant.Scores of two groups were significantly decreased in the 6th weeks,difference between groups was not significant,adverse reactions of two groups were no significant differences.Conclusion Ziprasidone combined with lithium is rapid onset,curative effects,less adverse reaction and higher security in treatment of manic episodes of bipolar disorder.