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2011•The Journal of Clinical PsychiatryRequires access

A comparative study of oxcarbazepine and lithium in the treatment of bipolar disorder with manic episode

Lao Hong-ya

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Abstract

Objective:To explore the efficacy and safety of oxcarbazepine and lithium in treatment of bipolar disorder with mania episode. Method:70 patients with bipolar disorder with mania episode randomized into single used oxcarbazepine group(35 cases) and lithium group(35 cases) for 8 weeks.Bech-Rafaelsen manic scale(BRMS) ,clinical global impressions severity scale(CGI-SI) and treatment emergent symptoms scale(TESS) were used to evaluate efficacy and side effects. Results:After treatment,BRMS and CGI-S score decreased significantly compared with before treatment(P0.05 or P0.01) ,there were no significant difference between two groups in score of BRMS and CGI-S(P0.05) .Two groups adverse events were mild. Conclusion:Oxcarbazepine and lithium are both effective and safe,in the treatment of bipolar disorder with manic episode.

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What this paper is about

Objective:To explore the efficacy and safety of oxcarbazepine and lithium in treatment of bipolar disorder with mania episode. Method:70 patients with bipolar disorder with mania episode randomized into single used oxcarbazepine group(35 cases) and lithium group(35 cases) for 8 weeks.Bech-Rafaelsen manic scale(BRMS) ,clinical global impressions severity scale(CGI-SI) and treatment emergent symptoms scale(TESS) were used to evaluate efficacy and side effects. Results:After treatment,BRMS and CGI-S score decreased significantly compared with before treatment(P0.05 or P0.01) ,there were no significant difference between two groups in score of BRMS and CGI-S(P0.05) .Two groups adverse events were mild. Conclusion:Oxcarbazepine and lithium are both effective and safe,in the treatment of bipolar disorder with manic episode.

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Available abstract

Objective:To explore the efficacy and safety of oxcarbazepine and lithium in treatment of bipolar disorder with mania episode. Method:70 patients with bipolar disorder with mania episode randomized into single used oxcarbazepine group(35 cases) and lithium group(35 cases) for 8 weeks.Bech-Rafaelsen manic scale(BRMS) ,clinical global impressions severity scale(CGI-SI) and treatment emergent symptoms scale(TESS) were used to evaluate efficacy and side effects. Results:After treatment,BRMS and CGI-S score decreased significantly compared with before treatment(P0.05 or P0.01) ,there were no significant difference between two groups in score of BRMS and CGI-S(P0.05) .Two groups adverse events were mild. Conclusion:Oxcarbazepine and lithium are both effective and safe,in the treatment of bipolar disorder with manic episode.

Key concepts: Oxcarbazepine, Mania, Lithium (medication), Bipolar disorder, Psychology, Treatment of bipolar disorder, Adverse effect, Psychiatry

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