2008•Journal of Hebei North UniversityRequires access
Effect of Kangnaoye on Gene Expression of Cortex Area Endogenous Stem Cells Factor
Zou Yu-an
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Abstract
Objective:To observe the expression of cortex area endogenous stem cells factor(SCF)mRNA in different phases after cerebral ischemia-reperfusion injury in rats under the intervention of Kangnaoye prescription.Methods:To establish the model of cerebral ischemia-reperfusion injury on middle cerebral artery in adult SD rats by the line hitch law,and divide them into model group,medicine intervention group and sham operation group randomly.Detect the expression of cortex area endogenous SCF mRNA when cerebral ischemia was 1.5 hours and reperfusion was after 1 day~14 days in Situ Hybridization.Results:After cerebral ischemia-reperfusion,the expression of medicine intervention group,model group SCF mRNA were obviously higher than that of sham operation group in the cortical area;at the 7th day,the expression of SCF mRNA reached the peak and began to decrease at the 14th day.Conclusion:The expression of cortex area endogenous stem cells factor(SCF)mRNA after the medicine intervention of cerebral ischemia-reperfusion injury has the same expression rule as the model group in the different phases.There is no significant difference in SCF mRNA expression of the two groups.