Effect of Platelet Associated IgG on the Count and Mature Degree of Megakaryocyte in Idiopathic Thrombocytopenic Purpura

Objective: Our aim was to investigate the relationship of platelet associated IgG ( PAIgG) and the count and mature degree of megakaryocyte in patients with idiopathic thrombocytopenic purpura (ITP) and its clinical significance. Methods:The PAIgG was detected by using quantitative competitive enzyme-linked immunoabsorbent assay (ELISA) in 586 patients with ITP. The count and mature degree of megakaryocyte were observed. Results:In the patients with increased PAIgG, a positive correlation existed between the increase of count of megakaryocyte and PAIgG level when level of PAIgG was between 175 and 500ng/10 7PA, but the opposite result was observed when level of PAIgG was higher than 500ng/10 7PA. With the increase of PAIgG, the mature of megakaryocyte was blocked significantly. The immature and granular megakaryocyte was increased and mature megakaryocyte which can produce platelet was decreased significantly. Conclusion:In the patients with ITP, there was a close relationship and certain correlation between the level of PAIgG and the count and mature degree of megakaryocyte.