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Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects

Toshiro Nagasawa, Yuichi Hasegawa, Seiichi Shimizu, Yasuko Kawashima, Shigeko Nishimura, Kazumi Suzukawa, Harumi Y. Mukai, Mitsuo Hori, Takuya Komeno, Hiroshi Kojima, Haruhiko Ninomiya, Tomoyuki Tahara, Tsukasa Abe

Open publisher page 46 citations

Abstract

A patient with idiopathic thrombocytopenic purpura (ITP) developed T-cell lymphoma while undergoing steroid therapy. We examined the relationship between the patient's serum thrombopoietin (Tpo) level, platelet count, megakaryocyte number and CFU-Meg number during the second 5 d course of chemotherapy for lymphoma in which megakaryopoiesis switched from ITP phase to amegakaryocytic phase. The patient's platelet count was temporarily elevated but CFU-Meg numbers were markedly suppressed, and megakaryocyte numbers were decreased in this period, whereas serum Tpo level was not suppressed despite an increased platelet count, indicating that serum Tpo level is mainly regulated by megakaryocyte mass.

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What this paper is about

A patient with idiopathic thrombocytopenic purpura (ITP) developed T-cell lymphoma while undergoing steroid therapy. We examined the relationship between the patient's serum thrombopoietin (Tpo) level, platelet count, megakaryocyte number and CFU-Meg number during the second 5 d course of chemotherapy for lymphoma in which megakaryopoiesis switched from ITP phase to amegakaryocytic phase. The patient's platelet count was temporarily elevated but CFU-Meg numbers were markedly suppressed, and megakaryocyte numbers were decreased in this period, whereas serum Tpo level was not suppressed despite an increased platelet count, indicating that serum Tpo level is mainly regulated by megakaryocyte mass.

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OpenAlex reports 46 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A patient with idiopathic thrombocytopenic purpura (ITP) developed T-cell lymphoma while undergoing steroid therapy. We examined the relationship between the patient's serum thrombopoietin (Tpo) level, platelet count, megakaryocyte number and CFU-Meg number during the second 5 d course of chemotherapy for lymphoma in which megakaryopoiesis switched from ITP phase to amegakaryocytic phase. The patient's platelet count was temporarily elevated but CFU-Meg numbers were markedly suppressed, and megakaryocyte numbers were decreased in this period, whereas serum Tpo level was not suppressed despite an increased platelet count, indicating that serum Tpo level is mainly regulated by megakaryocyte mass.

Key concepts: Thrombopoietin, Megakaryocyte, Platelet, Thrombopoiesis, Immunology, Medicine, Internal medicine, Biology

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Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects — Research Paper | ScholarLens