EXPERIMENTAL STUDY ON GERMICIDAL PROPERTY AND TOXICITY OF MONOPHYLETIC PREPARATION OF CHLORINE DIOXIDE DISINFECTION POWDER

The monophyletic preparation of chlorine dioxide disinfection powder is composed of 3 main ingredients.In order to know its germicidal efficacy and toxicity,suspension quantitative germicidal test and animal toxicity test were used to carry out laboratory study.Results: The average killing rate of Escherichia coli in suspension exposed to the water solution of the disinfectant containing chlorine dioxide 30 mg/L for 5 min was 99.95%,that of Staphylococcus aureus exposed to the disinfectant solution containing chlorine dioxide 15 mg/L for 5 min was 99.91% and that of spores of Bacillus subtilis var.niger exposed to the disinfectant solution containing chlorine dioxide 60 mg/L for 10 min was 99.94%.The disinfectant solution containing chlorine dioxide 200 mg/L with a 5 min contact time could destroy completely the antigenicity of HBsAg in suspension.More than 25%(v/v) calf serum in the bacterial suspension slightly influenced its efficacy in killing E.coli.The mouse acute oral LD_(50) of the chlorine dioxide disinfection powder was 5000 mg/kg,indicating that it belongs to non-toxic substances.The rabbit skin irritating test index of 100 mg/L chlorine dioxide disinfection solution was 0.63,indicating slight irritation.Conclusions: Monophyletic preparation of chlorine dioxide disinfection powder has good efficacy in killing vegetative form and spore of bacteria and is slightly irriating to rabbit skin.It belongs to non-toxic substances by animal toxicity test.