STUDY ON DISINFECTION RELATED PROPERTIES OF A COMPOUND POLY HEXAMETHYLENE BIGUANIDE HYDROCHLORIDE DISINFECTANT

Objective To study the disinfection related properties of a poly hexamethylene biguanide hydrochloride disinfectant.Methods Suspensionr quantitative germicidal test and animal toxic experiment were used to observe the germicidal efficacy and the toxicity of the compound disinfectant in laboratory.Results The killing logarithm values of Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa by the disinfectant solution containing poly hexamethylene biguanide hydrochloride 146 mg/L with 7.5 min contact time were all above 5.00.The killing logarithm value of Candida albicans and by the disinfectant solution containing poly hexamethylene biguanide hydrochloride 146 mg/L with 22.5 min contact time was 2.07.The LD50 of mice acute oral toxicity was 5 000 mg/kg·bw.The disinfectant has slightly-irritating to rabbit eye and mucosa and has medium irritating to rabbit skin.The result of mouse bone marrow polychromatic erythrocyte micronucleus test was negative.Conclusions The compound poly hexamethylene biguanide hydrochloride disinfectant had good germicidal efficacy to vegetative forms of bacteria.It was low toxicity and has slightly-irritating to rabbit eye and skin.