A control study of mirtazapine combined with amisulpride /quetiapine on the treatment of refractory depression

Objective To investigatethe efficacy and safety of mirtazapinecombined with amisulpride/quetiapine on the treatment of refractory depression.Methods Patients(n=84) with treatment-resistant depression were divided into amisulpride group(mirtazapine combinedamisulpride) and quetiapine group(mirtazapine combined quetiapine) randomly,the treatment last for 8 weeks,employing the Hamilton Depression Rating Scale(HAMD) and adverse reactions scale(TESS) to evaluate the efficacy and adverse reactions.Results Effective rate of Amisulpridegroup was 69.04%,and it was 71.43% for quetiapine group,but the differences of significant efficiency between the two groupspresent no statistically significant(χ2=0.057,P0.05),amisulpridegroup present effective more rapidlythan quetiapine group,and few adverse reactions wereobserved.But there were more patients in quetiapine group present drowsiness than amisulpride group.Conclusions Mirtazapine combined with amisulpride/quetiapine were effecttive for the treatment of refractory depression,adverse reactions for both group were mild,side effects of drowsiness in quetiapine group were less than that in amisulpride group,amisulpride group present effective more rapidly than quetiapine group.