2012•Journal of psychiatryRequires access

A comparative study of mirtazapine combining with quetiapine in the treatment of refractory depression

Wang Shengha

Abstract

Objective To investigate the clinical efficacy of mirtazapine combining with quetiapine in the treatment of refractory depression.Methods A total of 41 patients with refractory depression were randomly divided into study group(21 cases) treated with mirtazapine combining with quetiapine and control group(20 cases) treated with mirtazapine for 8 weeks.The efficacy and side effects were evaluated with Hamilton Depression Rating Scale(HAMD) and Treatment Emergent Symptom Scale(TESS) at the baseline and the 1st,2nd,4th,8th weekend.Results Scores of HAMD in two groups both decreased significantly(P0.05) after the treatment.Scores of HAMD in study group were significantly lower than that in control group at the 2nd,4th and 8th weekend(P0.05).There was significant difference in effective power between study group and control group(90.5% vs.60.0%,P0.05).The side effects in the two groups were mild.Conclusion Mirtazapine combining with quetiapine has satisfactory tolerability and has better efficacy than mirtazapine monotherapy in the treatment of refractory depression.

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Key concepts: Mirtazapine, Hamd, Quetiapine, Tolerability, Refractory (planetary science), Depression (economics), Hamilton depression scale, Medicine