Expressions of MIA2 and VEGF in primary hepatocellular carcinoma and their clinical significance

Objective To study the expressions of melanoma inhibitory activity-related gene 2(MIA2) and vascular endothelial growth factor(VEGF) in primary hepatocellular carcinoma(HCC).Methods The expressions of MIA2 and VEGF were determined by immunohistochemical staining method(SP) in 36 cases of HCC and 29 cases of the corresponding paracancerous tissues.Results The positive expression rates of MIA2 and VEGF expressions in HCC tissues were 41.7% and 77.8%,respectively.The expression of MIA2 and VEGF in HCC tissues had a positive correlation(P0.05).The positive expression rates of MIA2 and VEGF in the corresponding paracancerous tissues were 93.1% and 34.5%,respectively.There was a significant difference in MIA2 and VEGF expressions between HCC and paracancerous tissues(P0.01).Conclusion MIA2 expression is decreased or vanished in HCC compared with that in adjacent noncancerous tissues,and is closely associated with the differentiation,TNM staging and metastasis of HCC.The expression of MIA2 and VEGF have the negative correlation.