Expressions of VEGF and p53 in Primary Hepatocellular Carcinoma and Its Significance

Objective To study the expressions of vascular endothlial growth factor(VEGF) and p53 protein in primary hepatocellular carcinoma (HCC) and its significance. Methods The expressions of VEGF and p53 protein were determined by immunohistochemical staining method (SP) in 49 cases of HCC, 21 cases of corresponding paracancerous tissues and 10 cases of normal hepatic tissues. Results The positive rates of VEGF and p53 protein expressions in HCC tissues were 63.2% and 53.1% respectively.The expression of VEGF was positively correlated with expression of p53 in HCC tissues(P0.05). The positive rates of VEGF and p53 protein in the corresponding paracancerous tissues were 19.0% and 9.5% respectively.There was a significant difference in VEGF and p53 protein expressions between HCC and paracancerous tissues (P0.01).The expressions of VEGF and p53 were not detected in normal hepatic tissue.The expression of VEGF and p53 showed a significantly positive correlated with vascular invasion and metastasis (P0.05). Conclusions There are high expression rates of VEGF and p53 protein in HCC. VEGF associated with p53 influences microvessel density. Both p53 and VEGF may promote the HCC growth and metastasis by promoting the tumor angiogenesis.