Analysis of therapeutic time window and effect in acute cerebral infarction treated with intra-arterial thrombolytic therapy

Objective To analyze the effect and to discuss the factors that influence therapeutic time windows in acute cerebral infarction treated with intra-arterial thrombolytic therapy. Methods Fifty-four cases were examined by CT and angiography and received intra-arterial thombolytic therapy. Forty-two cases whose time from onset of stroke to beginning of thrombolysis were 6 hours, 12 cases were 12-96 hours. The recanalization rate and clinical outcome were statisticsed on two groups. Results The effectiveness rate of two groups was 88.1% and 75.0% respectively, the excellence rate was 71.4% and 50.0% respectively, the recanalization rate was 69.0% and 50.0% respectively, the reperfusive time of occluded artery was 68 and 73 minutes respectively. Conclusion The therapeutic time window was closely related to a lot of factors, it is not overall to be limited within 6 hours. Part of the cases with cerebral infarction after 6 hours of stroke onset can benefit from intra-arterial thrombolytic therapy.