Analysis of therapeutic time window and the effecting factors in acute cerebral infarction treated with intraarterial thrombolysis

Objective To analyze the clinical efficacy of intra-arterial thrmbolysis for acute cerebral infarction and to discuss factors affecting the therapeutic time window. Methods Fifty-four patients with acute cerebral infarction were acknowleged by CT and angiography and the underwent selective intra-arterial thrombolysis with one group of 42 cases within 6 hours after onset and another 12 between 6 and 24 hours. Vessel recanalization rate and neurological function deficit were evaluated after the procedure. Results The efficacies for the two groups were 88.1% and 75.0% , with excellent rates of 71.4% and 50.0 %, recanalization rates of 69.0% and 50.0%, and median times of recanalization of 68 and 73 minutes, respectively. Conclusion The therapeutic time window of intra-arterial thrombolysis was closely related to multiple factors and the standard time for treatment. The 6 hours of onset as standardization does not reflect all patients' conditions, the therapeutic time window should be reasonably elongated based on different patient's illness so as to decrease the mortality and morbidity on the largest scale and to increase the patient's living quality.