An analysis of glucose metabolism status and the relationship between the levels of PAI-1,hsCRP,HbA1c and coronary artery lesions in coronary heart disease patients with normal fasting blood sugar levels

Objective:To investigate the glucose metabolism status in coronary heart disease patients with normal fasting blood sugar levels and research on the relationship between the levels of plasminogen activator inhibitor-1(PAI-1),high-sensitive g-reactive protein(hs-CRP),glycosylated hemoglobin a1c(HbA1c) and coronary artery lesions in coronary heart disease patients with abnormal glucose tolerance.Methods:OGTT was performed in 226 cases who were confirmed coronary heart disease with coronary angiography,according to the oral glucose tolerance test(OGTT) results、 Patients were divided into 3 groups,which included NGT group with normal fasting blood sugar level,IGT group with impaired glucose tolerance,and T2DM group with type 2 diabetes mellitus.PAI-1,hsCRP,HbA1c were checked and the coronary narrow degree integral was calculated in all of the patients.Results:120 cases of abnormal glucose metabolism(53.1%) were found.Plasma PAI-1、hs-CRP、HbA1c levels and coronary narrow degree integrals were higher in both IGT group and T2DM group than that in NGT group(P0.05).Correlative analysis showed that plasma PAI-1、hs-CRP、HbA1c levels in coronary heart disease cases with IFG were positively correlated with the coronary narrow degree integrals(Gensini scores).Correlation coefficient was r=0.6082(P0.01),0.4443(P0.05) and 0.6327(P 0.01),respectively.Conclusion:The coronary multivessel lesions,severe lesions and diffuse stenosis are more frequent in coronary heart disease patients with IGT.The correlation between the plasma PAI1,hs-CRP,HbA1c levels and the severity of coronary artery lesions can reflect the severity of coronary artery lesions.