The effect of insulin resistance on coronary artery stenosis in coronary heart disease patients with different glucose tolerance

Objective:To study the influence of insulin resistance(IR) to coronary artery stenosis in patients with coronary heart disease(CHD).Methods:228 hospitalized patients with coronary heart disease diagnosed by coronary angiography were examined fasting and 2-hour postprandial plasma glucose by the 75g OGTT test.According to the test,228 patients were divided into three groups:the normal glucose tolerance(NGT) group(112 patients),the impaired glucose tolerance(IGT) group(56 patients),and the diabetes mellitus(DM) group(60 patients).Homeostasis model assessment(HOMA) index was used for quantitative analysis of IR.Gensini score was used for evaluation of severity of coronary artery stenosis in coronary atherosclerosis.Results:Gensini scores in the DM group and the IGT group are higher than that in the NGT group(P0.05).However,there was no significant difference between the DM group and the IGT group(P0.05).Gensini score was positively correlated with HOMA index.Conclusion:Coronary artery stenosis was more severe in the patients with IGT and CHD,and was positively correlated with the severity of IR.