The change regularity of serum soluble intercellular adhesion molecule-1 in patients with acute ischemic stroke and its clinical significance

Objective To investigate the change regularity of soluble intercellular adhesion molecule-1(sICAM-1) expression in patients with acute ischemic stroke,and explore the relationship with acute ischemic stroke.Methods Using Case-control study,Enzyme linked immunosorbent assay was employed to detect sICAM-1 in 135 cases with acute ischemic stroke and 40 heath examination as control group.Results The level of serum sICAM-1 in patients with acute ischemic stroke at 24 hours after the onset was higher than normal controls(P0.05),and which in patients group increased from 24 hours to 1 week,then decreased from 1 week to 2 weeks,but it was still higher than that in normal control group in 2 weeks;The level of serum sICAM-1 was significant higher in the patients with large cerebral infarction than that in patients with medium and small cerebral infarction(P0.01) and which with hypertension was significantly higher than that without hypertension(P0.01).Conclusion sICAM-1 may be closely related to the development of acute ischemic stroke and play important role in pathological procedure of cerebral damage after cerebral infarction.