The effect of rosuvastatin's intensive lipid-lowering function in patients with ischemic stroke

Objective To evaluate the effect of rosuvastatin′s intensive lipid-lowering function on plasma lipid and carotid atherosclerotic plaques in patients with ischemic stroke.Methods All of 72 cases of ischemic stroke patients were randomly divided into intensive group and general group.All patients were given conventional symptomatic treatment(reducing the intracranial pressure,control of blood pressure and blood glucose,anti-platelet,improving cerebral circulation,etc.),The general group were given rosuvastatin 10 mg qd orally,while the intensive group received rosuvastatin 20 mg qd orally for six months.Results After 6 months,TC,TG and LDL-C levels decreased significantly compared with those before treatment,HDL-C levels increased significantly compared with those before treatment(P 0.05 or P 0.01) in two groups of patients,and the range of decrease or increase is more obvious in the intensive group than that in the general group(P 0.05);and the plaque area and IMT were significantly reduced(P 0.05) compared with those before treatment in the intensive group,while there were no significant changes of plaque area and IMT(P 0.05) in the general group.The plaque area and IMT were significantly reduced compared with those in the general group(P 0.05) after treatment.Conclusion Rosuvastatin′s intensive lipid-lowering function has a stronger lipid-lowering effect on ischemic stroke,through reducing platelet adhesion and aggregation,thereby reducing the plaque area and carotid IMT,which may block and reverse carotid artery plaque progress.