Evaluation of long-term triple therapy with low-dose of pantoprazole and clarithromycin for the eradication of Helicobacter pylori

Objective To evaluate of long-term triple therapy with low-dose of pantoprazole and clarithromycin for the eradication of Helicobacter pylori.Methods Six hundreds patients with gastric ulcer or duodenal ulcer and Helicobacter pylori infection from 8 hospitals in our city were randomly divided into two groups.The control group were treated with pantoprazole 40 mg,amoxincillin 750 mg,and clarithromycin 250 mg,while the treatment group were treated with pantoprazole 20 mg,amoxincillin 750 mg,and clarithromycin 125 mg.The drugs were used orally twice per day,the course was two weeks.Results The eradication rate of Helicobacter pylori was 93.7% in treatment group,which was significantly higher than in control group(81.7%)(P=0.0081).Conclusion Two-week triple therapy with low-dose of pantoprazole and clarithromycin had a higher rate for eradication of Helicobacter pylori.