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2010•Anhui Medical and Pharmaceutical JournalRequires access

Pharmacokinetic investigation of Puerarin in Rats

Zhang Shan-tang

Open publisher page 1 citations

Abstract

Aim To investigate pharmacokinetics of puerarin in rats.Methods Puerarin was intragastrically given to the rats.The plasma concentration of puerarin was determined by HPLC.The data were processed by DAS 2.1.1 software to calculate the pharmacokinetic parameters.Results Chromatographic peaks for puerarin were separated well by the HPLC method.The main pharmacokinetic parameters for puerarin after oral administration were as follows:t1/2α was(0.549±0.397) h,t1/2β was(9.751±4.585) h,CL/F was(32.937±12.695) L·h-1·kg-1,Cmax was(0.545±0.051) mg·L-1,tmax was(0.799±0.183) h,AUC was(3.384±1.166) mg·L-1·h-1.Conclusion To establish a RP-HPLC method for the determination of plasma concentration of puerarin,for application in pharmacokinetic studies.It wil1 provide reference for puerarin reasonably use.

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What this paper is about

Aim To investigate pharmacokinetics of puerarin in rats.Methods Puerarin was intragastrically given to the rats.The plasma concentration of puerarin was determined by HPLC.The data were processed by DAS 2.1.1 software to calculate the pharmacokinetic parameters.Results Chromatographic peaks for puerarin were separated well by the HPLC method.The main pharmacokinetic parameters for puerarin after oral administration were as follows:t1/2α was(0.549±0.397) h,t1/2β was(9.751±4.585) h,CL/F was(32.937±12.695) L·h-1·kg-1,Cmax was(0.545±0.051) mg·L-1,tmax was(0.799±0.183) h,AUC was(3.384±1.166) mg·L-1·h-1.Conclusion To establish a RP-HPLC method for the determination of plasma concentration of puerarin,for application in pharmacokinetic studies.It wil1 provide reference for puerarin reasonably use.

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Available abstract

Aim To investigate pharmacokinetics of puerarin in rats.Methods Puerarin was intragastrically given to the rats.The plasma concentration of puerarin was determined by HPLC.The data were processed by DAS 2.1.1 software to calculate the pharmacokinetic parameters.Results Chromatographic peaks for puerarin were separated well by the HPLC method.The main pharmacokinetic parameters for puerarin after oral administration were as follows:t1/2α was(0.549±0.397) h,t1/2β was(9.751±4.585) h,CL/F was(32.937±12.695) L·h-1·kg-1,Cmax was(0.545±0.051) mg·L-1,tmax was(0.799±0.183) h,AUC was(3.384±1.166) mg·L-1·h-1.Conclusion To establish a RP-HPLC method for the determination of plasma concentration of puerarin,for application in pharmacokinetic studies.It wil1 provide reference for puerarin reasonably use.

Key concepts: Puerarin, Pharmacokinetics, Cmax, High-performance liquid chromatography, Chemistry, Chromatography, Pharmacology, Plasma concentration

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