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Pharmacokinetics of Xiaoer Reganning Injection in Rabbits

Jing Shu-han

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Abstract

OBJECTIVE:The pharmacokinetics of Xiaoer Reganning injection was determined in rabbits METHODS:The concentrations of puerarin in Xiaoer Reganning injection in plasma were determined by HPLC The analytical column was No _va-pak C18 (4μm,150mm×3 9mm ID) The mobile phase consisted of methol-water(20∶80) The detecting wavelength was 250nm The 3p87 program was used to calculate the pharmacokinetic parameters RESULTS:The in vivo pharmacokinetic course of puerarin in Xiaoer Reganning injection could be described as an open two-compartment model Its main pharmacokinetic parameters were as follows:T1/2(α)=5 25min,T1/2(β)=36 04min,K10=0 042min,K12=0 063min,K21=0 093min,AUC=2 561 49μg/(ml·min),CL=4 6ml/(min·kg) CONCLUSION:This study will provide a scientific basis for clinical use of Xiaoer Reganning injection

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OBJECTIVE:The pharmacokinetics of Xiaoer Reganning injection was determined in rabbits METHODS:The concentrations of puerarin in Xiaoer Reganning injection in plasma were determined by HPLC The analytical column was No _va-pak C18 (4μm,150mm×3 9mm ID) The mobile phase consisted of methol-water(20∶80) The detecting wavelength was 250nm The 3p87 program was used to calculate the pharmacokinetic parameters RESULTS:The in vivo pharmacokinetic course of puerarin in Xiaoer Reganning injection could be described as an open two-compartment model Its main pharmacokinetic parameters were as follows:T1/2(α)=5 25min,T1/2(β)=36 04min,K10=0 042min,K12=0 063min,K21=0 093min,AUC=2 561 49μg/(ml·min),CL=4 6ml/(min·kg) CONCLUSION:This study will provide a scientific basis for clinical use of Xiaoer Reganning injection

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Available abstract

OBJECTIVE:The pharmacokinetics of Xiaoer Reganning injection was determined in rabbits METHODS:The concentrations of puerarin in Xiaoer Reganning injection in plasma were determined by HPLC The analytical column was No _va-pak C18 (4μm,150mm×3 9mm ID) The mobile phase consisted of methol-water(20∶80) The detecting wavelength was 250nm The 3p87 program was used to calculate the pharmacokinetic parameters RESULTS:The in vivo pharmacokinetic course of puerarin in Xiaoer Reganning injection could be described as an open two-compartment model Its main pharmacokinetic parameters were as follows:T1/2(α)=5 25min,T1/2(β)=36 04min,K10=0 042min,K12=0 063min,K21=0 093min,AUC=2 561 49μg/(ml·min),CL=4 6ml/(min·kg) CONCLUSION:This study will provide a scientific basis for clinical use of Xiaoer Reganning injection

Key concepts: Pharmacokinetics, Puerarin, Chemistry, Chromatography, High-performance liquid chromatography, Pharmacology, Medicine, Pathology

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