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[Effect of decoction method on pharmacokinetics of puerarin in dogs].

Li Wang, Ying Zhao

Open publisher page 1 citations

Abstract

OBJECTIVE: To investigate the effect of decoction method on pharmacokinetics of Puerarin by determining Puerarin concentration of serum after administration of Gegenqinlian in single (D) and mixed decoction (H) to dogs. METHODS: HPLC method was established to determine serum concentration of Puerarin and pharmacokinetic parameters were calculated. RESULTS: The parameters in dogs after administration of H and D were as follows: C(max) was (5.164 +/- 0.637) and (5.383 +/- 0.818) microg/mL, t(max) was (1.10 +/- 0.374) and (1.25 +/- 0.274) h, AUC(0-t) was (25.76 +/- 5.48) and (27.97 +/- 7.16) microg/(h x mL), respectively. CONCLUSION: Decoction method has significant effect on pharmacokinetic parameters of puerarin in dogs.

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What this paper is about

OBJECTIVE: To investigate the effect of decoction method on pharmacokinetics of Puerarin by determining Puerarin concentration of serum after administration of Gegenqinlian in single (D) and mixed decoction (H) to dogs. METHODS: HPLC method was established to determine serum concentration of Puerarin and pharmacokinetic parameters were calculated. RESULTS: The parameters in dogs after administration of H and D were as follows: C(max) was (5.164 +/- 0.637) and (5.383 +/- 0.818) microg/mL, t(max) was (1.10 +/- 0.374) and (1.25 +/- 0.274) h, AUC(0-t) was (25.76 +/- 5.48) and (27.97 +/- 7.16) microg/(h x mL), respectively. CONCLUSION: Decoction method has significant effect on pharmacokinetic parameters of puerarin in dogs.

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Available abstract

OBJECTIVE: To investigate the effect of decoction method on pharmacokinetics of Puerarin by determining Puerarin concentration of serum after administration of Gegenqinlian in single (D) and mixed decoction (H) to dogs. METHODS: HPLC method was established to determine serum concentration of Puerarin and pharmacokinetic parameters were calculated. RESULTS: The parameters in dogs after administration of H and D were as follows: C(max) was (5.164 +/- 0.637) and (5.383 +/- 0.818) microg/mL, t(max) was (1.10 +/- 0.374) and (1.25 +/- 0.274) h, AUC(0-t) was (25.76 +/- 5.48) and (27.97 +/- 7.16) microg/(h x mL), respectively. CONCLUSION: Decoction method has significant effect on pharmacokinetic parameters of puerarin in dogs.

Key concepts: Puerarin, Decoction, Pharmacokinetics, Pharmacology, Chemistry, Medicine, Chromatography, Traditional medicine

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[Effect of decoction method on pharmacokinetics of puerarin in dogs]. — Research Paper | ScholarLens