2009•Chinese Journal of New Drugs and Clinical RemediesRequires access
Meta analysis on cinobufacini injection in hepatocellular carcinoma after transcatheter arterial chemoembolization
GU Xi-juna
Open publisher page 3 citations
Abstract
AIM To evaluate the efficacy of cinobufacini injection in the treatment of hepatocellular carcinoma after transcatheter arterial chemoembolization (TACE),based on available clinical data. METHODS Meta analysis was conducted on 10 studies about cinobufacini injection in hepatocellular carcinoma after TACE published from 2000 to 2008 in Chinese journals,and involved in relieve rate,effective rate,1 year survival rate,and 2 year survival rate. RESULTS No publication bias was detected in relieve rate,and publication bias was detected in effective rate,1 year survival rate,and 2 year survival rate. After the consistency check,all rates were homogenous (P 0.05),therefore,fixed effect model was applied. Odds ratio (OR) of relieve rate,effective rate,1 year survival rate,and 2 year survival rate were 1.87,2.80,2.55,and 2.61,respectively,and 95% confidence interval were 1.39 -2.52,1.96 -3.99,1.90 -3.42,and 1.96 -3.48,respectively. The relieve rate,effective rate,1 year survival rate,and 2 year survival rate of treatment group were significantly higher than those of the control group. CONCLUSION Cinobufacini injection is effective in the treatment of hepatocellular carcinoma after transcatheter arterial chemoembolization.