Small cell lung carcinoma:a clinicopathologic analysis of 53 cases

Objective To investigate the clinicopathologic characteristics,immunohistochemical features,and histogenesis of the small cell lung carcinoma. Methods The clinical data,pathological findings,and results of immunohistochemical staining were retrospectively studied in 54 cases of small cell lung carcinoma. Results In all the types of lung carcinomas,small cell lung carcinoma accounted for 17.04%;The ratio of man to woman was 2.8 to 1;The average age was 56.7 years old;The average time from the appearance of symptoms to clinical detection was 59.3 days;65.22% of cases had lymph node metastasis.The positive ratie of immunohistochemical staining for neuroendocrine markers was 88.89%,71.43% and 60% for NSE,CgA and Syn,respectively,and the total positive rate of neuroendocrine markers was 75%(21/28);The positive rate of epithelial marker, CKpan,was 100%,but lymphocytoid marker,LCA,was not detected. Conclusion Small cell lung carcinoma is a high malignant tumor,with rapid progression and early metastasis.Both neuroendocrine and epithelial markers are positive to this tumor.The results suggest this tumor may orign from the bronchi mucosa stem cells.