Small cell carcinoma of the lung:a clinicopathologic analysis

Objective To its diagnosis and explore the histopathologic and immunohistochemical characteristics of small cell carcinoma of the lung and its diagnosis and differential diagnosis.Methods We observed the histopathologic and immunohistochemical results in 8 cases of small cell carcinoma and the related literature was reviewed.Rusults Histologically,the majority of the tumor was composed of cords or nest or sheets or loose aggregates of small cell;it had minor component of squamous and glandular differentiation.Immunohistochemically,the tumor cells were positive CK、CEA,the partly small cells were positive for Syn、CgA.Conclusions Small cell carcinoma of the lung is a malignant tumor.It has a characteristic histopathologic pattern.Differential diagnosis of it includes lymphoma,primitive neuroectodermal tumour,Merkel cell carcinoma,non-small carcinoma,large cell neuroendocrine,carcinoid.