Effects of compatibility of Salvia miltiorrhiza Bge and Panax notoginseng on chronic liver injury in rats

Objective: To observe whether Salvia miltiorrhiza Bge is compatible with Panax notoginseng in chronic liver injury in rats. Methods: Chronic liver injury rat model was prepared by CCl 4.Levels of serum alanine aminotransferase (ALT), albumin, globulin, hyaluronic acid (HA) and laminin (LN) and hydroxyproline(Hyp) in the liver tissue were determined to reveal the extent of liver damage, The hepatic histomorphology was examined by HE staining. Results: The extent of liver damage, fatty degeneration and infiltration of inflammatory cells were less severe in Salvia miltiorrhiza Bge compatible with Panax notoginseng group than in the CCl 4 group. The formation of fibroblasts and collagenous fibers was less in Salvia miltiorrhiza Bge compatible with Panax notoginseng group than in the CCl 4 group. Conclusion: Salvia miltiorrhiza Bge compatible with Panax notoginseng had better effects on the recovery of impaired hepatic organization and promoted liver cell regeneration.