Protective action of salvia miltiorrhiza and panax notoginseng on ethanol-induced stomach and liver injury in rats

【Objective】 To investigate the protective action of salvia miltiorrhiza combined notoginseng on ethanol-induced stomach and liver injury in rats. 【Methods】Eighty SD rats were divided into 4 groups randomly with twenty rats in every group: blank control group, model control group with gastric and hepatic injury group and two experimental groups(extract 2.4, 0.8 g/kg respectively). Ethanol was given to rats by oral gavage once in order to make the stomach and liver injury model at the end of experiment. Proportion of gastric mucous membrane injury was measured usingthe slide gauge with precision of 0.001 millimeter. The content of MDA and TG and GSH in hepatic tissue and the levels of somatostatin(SS), pepsinogen(PG) of gastric tissueswere detected by kits accordingly.The pathological changes in hepatic tissue and gastric mucous membrane were determined. 【Results】The contents of MDA and TG of liver tissue were weakened and the content of GSH was increased in the high dose group, and the levels of somatostatin(SS), pepsinogen(PG) of gastric tissues were increased. Pathological accumulate points of gastric mucosa and liver were decreased in high group, and it showed significant difference compared with the model control group. 【Conclusion】The combination of salvia miltiorrhiza and panax notoginseng has the function of protecting the liver and gastric tissue from ethanol-induced injury.