The clinincal effect of different doses of fluvastatin in the treatment of elderly patients with coronary artery disease and hyperlipidemia

Objective To explore the clinincal effect of different doses of fluvastatin in treatment of elderly patients with coronary artery disease and hyperlipidemia and its mechanism.Methods 86 aged patients with coronary heart disease and hyperlipidemia were randomly divided into group 20 mg and group 40 mg.The cases in 20 mg group was given fluvastatin 20 mg/d treatment and 40 mg group received fluvastatin 40mg/d treatment,12 weeks for a course.Results The total effective rate in 20 mg group and 40 mg group was 81.40% and 88.37%,no significant difference between the two groups(P0.05).The levels of TC,LDL-C,TG and hs-CRP in two groups of patients after treatment were significantly lower compared with that in the same group before treatment(P0.05).The level of HDL-C in two groups after treatment was significantly higher than that before treatment(P0.05).The reduction of TC,LDL-C,hs-CRP and increase of HDL-C in group 40 mg after treatment were more effective than group 20 mg(P0.05).Conclusion The effect of fluvastatin 40 mg qd is superior to that of fluvastatin 20 mg qd,which could improve the short-term efficacy of patients with coronary heart disease and the mechanism may be related to regulation of serum hs-CRP levels,reduced endothelial inflammatory state,regulation of vascular endothelial function.