Valsartan and benazepril in elderly patients with mild to moderate essential hypertension

Objective:To observe the effect of valsartan and benazepril in the treatment of mild to moderate primary essential hy-pertension.Methods:72 cases diagnosed as mild to moderate essential hypertension were randomly divided into valsartan group(37 cas-es)and benazepril group(35 cases).The two groups were respecively given valsartan 80 mg,benazepril 10 mg on the morning.The total ob-servation time was 6 weeks.In 1,4,6-week medication,blood pressure was measured.After 6 weeks of medication,serum potassium,liver function,kidney function and blood lipids were measured.Results:After 1,4,6-week medication,blood pressurein the two groups signifi-cantly decreased than before treatment(P0.05).The difference between the two groups was not statistically significant(P0.05).At the end of 6 weeks,the antihypertensive effective rates in valsartan and benazepril groups were 78.37% and 75.75% respectively.At the end of 6 weeks,compared with before treatment,serum potassium,liver function,renal function had no significant change.In valsartan group,TC,TG,LDL-C was significantly lowered,HDL-C had no significant change.Conclusion:Valsartan and benazepril on the elderly patients with mild to moderate primary hypertensive have better effect lowering blood pressure,which is safe to take.Valsartan can improve lipid metabolism in hypertensive patients.