Effects of Valsartan or Benazepril on Blood Pressure and Insulin Resistance in Patients with Mild to Moderate Essential Hypertension

Objective:To observe the clinical efficacy of valsartan and benazepril in the treatment of patients with mild to moderate essential hypertension.Methods:A total of 87 patients with mild to moderate essential hypertension were randomly divided into A group(n=44)and B group(n=43).The patients in A group were treated with 80 mg valsartan everyday,and the patients in B group were treated with 5~10mg benazepril everyday.The patients of two groups were both treated for four weeks.Before and after treatment,24h ambulatory blood pressure monitoring(ABPM),fasting blood glucose(FBG)and fasting insulin(FINS)were detected respectively,and homeostasis model assessment-insulin resistance(HOMA-IR)and homeostasis model assessment-insulin sensitive(HOMA-IS)were obtained.Results:After four weeks of the treatments,blood pressures,HOMA-IR and HOMA-IS all declined obviously in both groups(P0.05),but there were no significant difference between A group and B group(P0.05).Conclusion:Valsartan and benazepril might decrease blood pressure of patients with mild to moderate essential hypertension,both could improve insulin resistance.