Effectiveness of Interferon-alpha 2b combined with Lamivudine therapy in patients with chronic hepatitis B

Objective To inderify the efficacy of combination treatment of Lamivudine and INF-α 2b in patients with chronic hepatitis B.Methods Ninety patients with CHB were divided into two groups casually.The treating group(n=42) was treated with INF-α 2b combined with Lamivudine.While the control group(n=48) was treated with Lamivudine only.HBVDNA,liver function indexes and HBeAg/HBeAb conversion ratio in the plasma of those patients were observed.Results The negative rate of serum HBVDNA and liver function indexes in treating group were obvious better than those in control group at the end of 48 weeks' treatment.The complete response rate was 40.5% in treating group,which was higher than that in control group(22.9%)(P0.01) .After 24 weeks follow up,those were still higher in the treating group than in control group.Conclusion Combination of Lamivudine and INF-α 2b in the treatment of patients with CHB can get a better effect,which might improve complete response and decrease YMDD mutation.