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2010•Internal Medicine of ChinaRequires access

Long-term effect of interferon alpha-2b combined with lamivudine in treatment for of chronic hepatitis B patients

Yong Liang

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Abstract

Objective To study the effect of interferonα-2b and Lamivudine in chronic hepatitis B patients with a longer course of treatment.Methods 137 patients were enrolled and randomized into two groups.61 patients received interferonα-2b and lamivudine simultaneously for 52 weeks,then lamivudine alone for 52 weeks (combination group).76 patients received lamivudine alone for 104 weeks (control group).Results There was no difference between two groups in HBV DNA response and ALT normal rate (P=0.24).Proportion of HBeAg/Anti-HBe serum conversion in combination group was significantly higher than control group (42.6% vs.26.3%,P=0.045).HBV YMDD mutation rate in combination group was lower than in lamivudine group (14.5% vs.40.8%,P=0.001).Conclusion The efficacy of combination therapy is better than lamivudine mono-therapy.Combination treatment may diminish the development of HBV YMDD mutation.

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Objective To study the effect of interferonα-2b and Lamivudine in chronic hepatitis B patients with a longer course of treatment.Methods 137 patients were enrolled and randomized into two groups.61 patients received interferonα-2b and lamivudine simultaneously for 52 weeks,then lamivudine alone for 52 weeks (combination group).76 patients received lamivudine alone for 104 weeks (control group).Results There was no difference between two groups in HBV DNA response and ALT normal rate (P=0.24).Proportion of HBeAg/Anti-HBe serum conversion in combination group was significantly higher than control group (42.6% vs.26.3%,P=0.045).HBV YMDD mutation rate in combination group was lower than in lamivudine group (14.5% vs.40.8%,P=0.001).Conclusion The efficacy of combination therapy is better than lamivudine mono-therapy.Combination treatment may diminish the development of HBV YMDD mutation.

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Available abstract

Objective To study the effect of interferonα-2b and Lamivudine in chronic hepatitis B patients with a longer course of treatment.Methods 137 patients were enrolled and randomized into two groups.61 patients received interferonα-2b and lamivudine simultaneously for 52 weeks,then lamivudine alone for 52 weeks (combination group).76 patients received lamivudine alone for 104 weeks (control group).Results There was no difference between two groups in HBV DNA response and ALT normal rate (P=0.24).Proportion of HBeAg/Anti-HBe serum conversion in combination group was significantly higher than control group (42.6% vs.26.3%,P=0.045).HBV YMDD mutation rate in combination group was lower than in lamivudine group (14.5% vs.40.8%,P=0.001).Conclusion The efficacy of combination therapy is better than lamivudine mono-therapy.Combination treatment may diminish the development of HBV YMDD mutation.

Key concepts: Lamivudine, Medicine, HBeAg, Gastroenterology, Internal medicine, Chronic hepatitis, Interferon, Combination therapy

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