Effect of hyperin on acute liver injury in rats against oxidative stress-induced by CCl_4

Objective To study the protective effect of hyperin( Hyp) on the acute liver injury in rats induced by CCl 4. Methods The acute liver injury model was induced by CCl 4. The effect of Hyp on acute liver injury of rat liver histopathology was observed; and the impact of changes of homogenates total superoxide dismutase( T-SOD),glutathione( GSH) activity and malondialdehyde( MDA) in liver were detected. Results The acute liver injury of tissue induced by CCl 4,apparent pathological inflammation and fibrous tissue degeneration and necrosis were observed by HE staining; At the high doses of 60 mg/kg and medium doses of 30 mg/kg treated by Hyp,liver pathology changes was significantly obvious. The T-SOD,GSH activity of liver tissue was significantly increased in the groups of Hyp treatment,MDA content was significantly decreased,which related to the dosages. Conclusion In the rat model of acute liver injury induced by CCl 4. A better therapeutic effect of Hyp was shown,the mechanism may be related to its antioxidant activity.