The influence of Suanzhiqing capsules on rat( of acute gouty arthritis) model's IL-1beta and TNF-alpha

Objective By observing the effective of the experimental gouty arthritis model's IL-1beta and TNF-alpha in rats to find its clear anti-inflammatory mechanism of action and its effective to cartilage destruction and advising clinical medicine.Methods With the extraction of proprietary Chinese medicines Suanzhiqing capsules( water extraction,ethanol extraction) intragastric injection administration to the rats of acute gouty arthritis caused by uric acid sodium model for 7 days. And respectively at 9h and 12h randomly selected six rats in each group to measure the diameter of the ankle joint then take the inferior vena cava blood with ELISA detection to disclose the amount of inflammatory cytokines. Results Chinese medicine and western medicine( colchicine) groups' proinflammatory cytokines were significantly lower compared with the model group,and the water extract group loss was the most obvious. Conclusion Suanzhiqing capsules worked by control the level of IL-1β and TNF-α to anti-inflammatory and protect articular cartilage. The best role was in the water extract group.