2010•Shijie zhongxiyi jiehe zazhiRequires access
Regulation of Baiai Tongfengling Mianjian Granule on Inflammatory Cytokines in Acute Gout Model
Guodong Huang
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Abstract
Objective To investigate the mechanism of baiai tongfengling mianjian granule on acute gouty arthritis.MethodsTo establish acute gouty arthritis model in rabbits,observe the impacts of baiai tongfengling mianjian granule on the expression of TNF-α and IL-1β in joint fluid in rabbits modeled with acute gouty arthritis and make the comparison among model group,colchicine western medicine group and normal group.ResultsThe content of TNF-α and IL-1β in joint fluid of model group were obviously higher than that in normal control group(P0.01).The content of TNF-α and IL-1β in baiai tongfengling Chinese herb group and colchicine western medicine group was lower apparently than that in model group(P0.01).There was no apparent difference in the content of TNF-α and IL-1β in baiai tongfengling Chinese herb group and colchicine western medicine group as compared with that in normal group.ConclusionBaiai tongfengling mianjian granule has a certain effect on acute gouty arthritis.