2012•Zhongguo shiyan fangjixue zazhiRequires access
Immunoregulatory Effects of Qushi Chubi Medicines in Rats with Acute Gouty Arthritis
Jianxiong Chen
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Abstract
Objective:To observe the immunoregulatory effects of Qushi Chubi medicines on gouty arthritis in rats models to prove the hot and humid block the main mechanism of acute gouty arthritis.Method: Forty SPF Wistar ratswere randomly divided into blank group,model group,colchicine group,traditional Chinese medicine low-dose group and high-dose group,8 rats in each group.The uric acid sodium crystals were injected in rat ankle to establish acute gouty art-hritis model.the dysfunction index of rats was observe,and the inflammatory cells(lympho-cytes) in joint tissue was determineed.The expression levels of interleukin-1β(IL-1β)and interleukin-1R(IL-1R)and myeloid differentiation factor 88(MyD88) in joint tissue were assayed.Result: Each dose group of the Chinese medicines could significantly improve the dysfunction in rats and reduce the number of inflam-matory cells of joint tissues and inhibit the expression of inflammatory cytokines in the joint organization.Chinese medicine high-dose group was more effective than the colchicine group.Conclusion: The Qushi Chubi medicines can effectively inhibit the expression of inflammatory cells and the inflammatory cytokines in rats with acute gouty arthritis.It is the effective method for acute treatment of gouty arthritis.