2007•Journal of clinical and experimental medicineRequires access
Changes in serum RBP and PAB levels in patients with cirrhosis
LU Fang-ge
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Abstract
Objective To investigate the changes in serum RBP and PAB levels in patients with cirrhosis and its clinical significance.Methods 116 cirrhotic patients were divided into grade A,grade B and grade C according to the Child Pugh score in ascending order.Control group consisted of 50 healthy subjects.The serum RBP,PAB and ALB concentration was measured with automatic biochemical analyzer.Results RBP concentration was significantly decreased in grade A patients than in control group(F=2.98,P0.05),while ALB and PAB concentration was not significantly different.There were significant differences in serum RBP,PAB and ALB concentration between Grade B or Grade C and control group.RBP and PAB are more sensitive than ALB.Serum RBP was positively correlated with PAB(r=0.769,P0.01),serum RBP and PAB were also positively correlated with ALB(r=0.608,r=0.534,P0.05).Conclusion Serum RBP and PAB progressively decrease with the increase in Child Pugh grade.RBP and PAB are more sensitive than ALB.Combined analysis of RBP and PAB help to determine hepatic function,prognosis and treatment of cirrhotic patients.