Clinical expression of BP1 in breast cancer tissues and its correlation with the expression of Bcl-2

Objective To explore the clinical expression of BP1 in breast cancer tissues and its correlation with the expression of Bcl-2.Methods 72 breast cancer tissues samples from 72 patients of breast cancer who were randomly selected and underwent surgical treatment from May 2012 to May 2013 in our hospital were as the study group,and 72 carcinoma tissues samples from the same patients were as the control group.The patients of two groups were done the positive test by the Westem blot and immunohistochemical methods,and the positive expression of BP1 protein of two groups,correlation between expression of BP1 and Bcr-2 and between expression of BP1 and pathologic factors of breast cancer in the study group were analyzed.Results The positive expression of BP1 in the study group was higher than that in the control group,the difference was statistically significant(P0.05);The positive expression of Bcl-2 protein and BP1 in the study group had positive correlation(P0.05).The positive expression of BP1 and PR,ER and C-erb-B-2 in pathological factors of breast cancer had correlation(P0.05).Conclusion The positive expression of BP1 protein in breast cancer tissues is associated with the occurrence and development of breast cancer,and can promote the rise of the Bcl-2 expression,has a certain clinical research and application value.