Clinical effects of flurbiprofen axetil on preemptive analgesia during radical operation of thyroid cancer

Objective:To observe the preemptive analgesia effect of flurbiprofen axetil during radical operation of thyroid cancer.Methods: Fourty patients undergoing radical operation of thyroid cancer were randomly divided into two groups.Patients in both groups received general analgesia.After tracheal intubation,the patients in group A(n=20) received intravenous of flurbiprofen axetil 100mg before surgery,and those in group B(n=20) received intravenous of flurbiprofen axetil 100mg after suturing the incision.Patients controlled analgesia(PCA) was not used in two groups.Postoperative analgesia efficacy was assessed by Visual Analogue Scales(VAS) at 0.5h,4h,8h,12h and 24 h after extubation,and adverse reaction of flurbiprofen axetil were also observed.Results: VAS were significantly higher in group B during 24h after surgery compared with those in group A(P0.05).The adverse reactions were similar between two groups.Conclusion: Preemptive analgesia of flurbiprofen axetil can effectively alleviate the pain in radical operation of thyroid cancer.