Effects of TaizijianII decoction on EOS and ET-1 in guinea pigs of allergic asthma

Objective To observe the effect of TaizijianⅡ decoction(TZJⅡ) on EOS and ET-1 of guinea pig asthma models.To explore the mechanism of TZJⅡ on anti-relapsing children asthma.Methods 50 guinea pigs were divided into 5 groups randomly,normal control group,asthma model group,dexamethasone group,high-dose TZJⅡ group and low-dose TZJⅡ group.The five groups were sensitized with ovalbumin,and induced asthma successfully.After that each group were given different preventive and treatments for 15 days.Then the number of eosinophils(EOS) in peripheral blood,bronchoalveolar lavage fluid(BALF) and bronchial wall were counted by counting plate.The content of ET-1 in BALF were measured by radioimmunity methods.Results High-dose TZJⅡ could reduce the number of EOS in BALF and bronchial wall(P0.05),lower the ET-1 content in BALF(P0.01) compared with guinea pig asthma models.Conclusion TZJⅡ can lessen EOS infiltration and regulate ET-1 production,suggesting that it might take effect in alleviating the chronic airway inflammation.