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Effects of Zhisoulixiao Granule on airway allergy inflammation in guinea pig with asthma

Qiuying Yu

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Abstract

Objective:To establish asthma model using Guinea pig to study the effects of Zhisoulixiao on airway allergic inflammation.Methods:Eosinophil(EOS) cell counts and interleukin-5(IT-5) content in blood and bronchial alveolar lavage fluid(BALF) were determined in Guinea pig with asthma after being infected with ovalbumin through gastritic injection at different dosages of Zhisoulixiao.Results:The EOS and IL-5 levels in blood and BALF in the asthma group were greater than those of the control group significantly(P0.01).Additionally,the EOS and IL-5 levels of Zhisoulixiao groups were lower than those of the asthma groups significantly(P0.01).Conclusion:Zhisoulixiao can inhibit the airway allergic inflammation of asthma animals and its mechanism seems to reduce EOS and IL-5 levels in blood and BALF.

About this research paper

What this paper is about

Objective:To establish asthma model using Guinea pig to study the effects of Zhisoulixiao on airway allergic inflammation.Methods:Eosinophil(EOS) cell counts and interleukin-5(IT-5) content in blood and bronchial alveolar lavage fluid(BALF) were determined in Guinea pig with asthma after being infected with ovalbumin through gastritic injection at different dosages of Zhisoulixiao.Results:The EOS and IL-5 levels in blood and BALF in the asthma group were greater than those of the control group significantly(P0.01).Additionally,the EOS and IL-5 levels of Zhisoulixiao groups were lower than those of the asthma groups significantly(P0.01).Conclusion:Zhisoulixiao can inhibit the airway allergic inflammation of asthma animals and its mechanism seems to reduce EOS and IL-5 levels in blood and BALF.

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Available abstract

Objective:To establish asthma model using Guinea pig to study the effects of Zhisoulixiao on airway allergic inflammation.Methods:Eosinophil(EOS) cell counts and interleukin-5(IT-5) content in blood and bronchial alveolar lavage fluid(BALF) were determined in Guinea pig with asthma after being infected with ovalbumin through gastritic injection at different dosages of Zhisoulixiao.Results:The EOS and IL-5 levels in blood and BALF in the asthma group were greater than those of the control group significantly(P0.01).Additionally,the EOS and IL-5 levels of Zhisoulixiao groups were lower than those of the asthma groups significantly(P0.01).Conclusion:Zhisoulixiao can inhibit the airway allergic inflammation of asthma animals and its mechanism seems to reduce EOS and IL-5 levels in blood and BALF.

Key concepts: Medicine, Ovalbumin, Asthma, Eosinophil, Immunology, Guinea pig, Allergy, Dose

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Effects of Zhisoulixiao Granule on airway allergy inflammation in guinea pig with asthma — Research Paper | ScholarLens