Effect of penehyclidine hydrochloride on intrapulmonary shunt and inflammatory factors during one lung ventilation in patients receiving thoracic surgery

AIM: To observe the effect of penehyclidine hydrochloride on intrapulmonary shunt and inflammatory factors in lung cancer surgery. METHODS: Thirty patients with lung cancer undergoing lung resection were randomly divided into two groups with 15 cases each: penehyclidine hydrochloride group(group A) and atropine group(group B).Blood gas analysis,TNF-α,IL-6,IL-8,SOD and MDA concentrations were detected at two lung ventilation(TLV)(T1,baseline),OLV 45 min(T2),OLV 90 min(T3) and 2 h,24 h after operation(T4,T5).RESULTS:SPO2,PaO2 were lower in group B than those in group A,Qs/Qt was higher than group A at T2-4(P0.05).Serum TNF-α,IL-6,IL-8 SOD concentrations were lower at T3-5 in group A than those in group B(P0.05).Serum MDA concentration was higher at T3-4 in group B than in group A.CONCLUSION: Penehyclidine hydrochloride could reduce intrapulmonary shunt and alleviate the pulmonary inflammatory reactions in lung cancer surgery.